![]() Unfortunately, there are currently no effective treatments for neurodegenerative diseases nor biomarkers for their early detection ( Heemels, 2016). Neurodegenerative diseases are characterized by a chronic and progressive structural and functional degeneration of cells in the central or peripheral nervous system, leading to massive neuronal loss. We conclude by highlighting challenges and limitations in the application of these technologies in the study of AD and PD. Moreover, we review some examples of the computational and analytical tools required to interpret the extensive amount of data generated from these assays. We discuss the fundamental principles and implications of single-cell sequencing of the human brain. Herein we review the recent progress in understanding these neurodegenerative diseases using these state-of-the-art technologies. Exciting research using high throughput scRNA-seq and snRNA-seq technologies to study AD and PD is emerging. This technology has allowed the identification of cell types and states, providing new insights into cellular susceptibilities and molecular mechanisms underlying neurodegenerative conditions. Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq) have become powerful tools to elucidate the inherent complexity and dynamics of the central nervous system at cellular resolution. Two types of common neurodegenerative diseases are Alzheimer’s (AD) and Parkinson’s disease (PD). Neurodegenerative diseases affect millions of people worldwide and there are currently no cures.
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